The selected teams from the “first phase” are asked to attend two mentoring sessions given by the consultants of Macorig &Co. The appointments for the two mentoring sessions will be given once the Entry Team has accomplished the Registration procedure in a correct way. It is warmly suggested to start to study, and possibly start to complete, the Business Plan model before the mentoring sessions in order to have a draft of the document ready for discussion.
Finalist Teams announced!
After evaluating 45 Executive Summaries, the Concept Jury has selected the 15 teams which will attend the Boot Camp and the Selection Event of the 8th edition of Nanochallenge&Polymerchallenge in Padua from 27th to 31st October, 2012
The selected teams are (in alphabetical order)
ALIA MENTIS is a company-laboratory where a creative vision of the future meets scientific research to develop technological solutions which until now were the stuff of dreams. At Alia Mentis we identify a high-end market aim and give life to the technologies needed to make it a reality. This whole process takes place within an innovative model of company analysis and management which seeks to form the company around the ideas, instead of forcing ideas to conform to the company. Every project has its specific team, totally tailored on it and covering every specific or key needs.
Members are worldwide selected trough a deep profiles search working trough specific databases, personal publications, patents deposit and direct/indirect Skills reputation. Alia-Mentis submit to Nanochallenge event its first creature: Logic-Coating It is a modular technology platform that brings together a series of highly strategic and innovative functions for the electronic needs. 3D Circuits, light, energy generation and storage are fully integrated within a secial polymer that transforms the object’s surface into a powerful active device. Once in the hands of a designer will enable the creation of unique applications, extreme functionalities and new freedom on shape making for the products th ey design.
BioComposite Ltd is an R&D startup company that will be established in Naples, Campania. The company mission is the development of innovative therapeutic nanohybrids in the field of bone tissue engineering. Biocomposite will uniquely combine a novel ceramics sol-gel preparation method with nanostructured, biocompetent hyperbranched polymers to provide injectable materials able to stimulate bone regeneration. R&D activity will be interested to fulfill the specific need of patients and surgeons; the technological platform will be a valid alternative to the clinical requirements in the orthopedic and periodontal surgery. The idea is to realize a business where the R&D and capability of the team will be used to exploit the innovation through licensing of the intellectual properties to biomedical companies that operate in the field of tissue engineering.
Immunogenicity is defined as the immune response, meaning production of specific antibodies, triggered by an exogenous (“non-self”) protein once it enters the human body. In the case of protein drugs, this phenomenon leads to the production of Anti-Drug Antibodies (ADA) that compromise the efficacy of the drug itself and in some cases anaphylaxis and autoimmunity. The business idea of EpiDyne is about the development and commercialization of services based on innovative computational methods for the assessment (immunogenicity screening) and engineering (deimmunization) of proteins for potential therapeutic use with the objective to minimize the risk of immunogenicity.
HELIV proposes illuminating transparent surfaces that synergistically combine functionality with design aesthetics, innovatively based on the latest scientific findings in nanotechnology. This union of features allows for a vast realization of products, aimed at but not restricted to, the sectors of visual communication, lighting and furniture manufacture. Based on a technology which is readily accessible, Heliv technology can be integrated into existing products, is eco-friendly offering reduced energy consumption, the illuminating surfaces can be favorably produced within a reasonable cost.
INNOVA Nano, a Research Unit of INNOVA Onlus, Translation in Medical Research
Nanotechnology offers the opportunity to develop novel micro\nano-carriers for targeted drug therapy, reducing undesirable side effects. In the proposed project, our team will fabricate multifunctional, highly biodegradable and biocompatible, drug-loaded micro\nano-capsules with the following features: 1) to protect drugs from chemical and biological degradation; 2) to monitor their in vitro and in vivo distribution; 3) to target specific cells (i.e. Hepatocellular Carcinoma (HCC)). Biodegradable polyelectrolyte pairs (eg polysaccharides) with opposite charge will be utilised by the layer-by -layer selfassembly technique on colloidal cores like calcium carbonate. The cores will subsequently be dissolved to yield hollow capsules ready to encapsulate drugs. Selected fluorophores and magnetic nanoparticles will be included in the coating to allow in vitro and in vivo monitoring of micro\nano-capsule fate. Ligands will be conjugated to the coating layers in order to allow specific cellular targeting (eg to HCC cells). The internalisation and cytotoxicity of drug-loaded micro\nano-capsules will be evaluated on cell lines in vitro. The research objectives will drive to: – Development of new bio-products for cancer prevention – Development of novel multifunctional nano-carriers for cancer therapy The present proposal is aimed to the set up new processes For the production and delivery of natural compounds as anticancer drugs – Production of natural products and functional food for pharmaceutical administration – Production of nanocapsules for anti-neoplastic, drug-loading and targeted delivery
MRS is a R&D, mechanical design and service provider company with a focus on material recovery systems applied to thin-film deposition processes. Its mission is providing breakthrough technology, in order to increase the efficiency of PVD (Physical Vapour Deposition) processes, today used to produce microchips, MEMS (Micro Electro-Mechanical Systems), solar cells and other nanotech devices. Deposition plants lose a lot of precious materials: every year about 15 tons of gold become a production waste. Our technology makes possible to recover up to 70% of this fraction. If compared to the state of the art, our solution reduces the downtime, allows in-situ recovery, representing a cleantech alternative
NARRANDO (NAno caRbon_RAdiatioN DOsimeter)
The clinical use of ionizing radiation to obtain a necrosing or cytotoxic radiobiological effect on tumoral lesions requires complex physical and dosimetric procedures in order to treat the tumor saving the surrounding healthy tissues. It is necessary to avoid overexposing or ineffective therapy. Moreover, according to the commercial insights and scientific literature, the main technical characteristics, also evaluated by customers in buying such a kind of device, are accuracy, independence from environment conditions, real time response, in vivo applications, space resolution, absolute dose measurement. Therefore, a new priority target in radiotherapy is the research and development of improved detectors. Ionization chambers are considered the most important dosimeters because they allow absolute dose measurements and are characterized by high accuracy, practicality and reliability. However, they have a relative large physical size which limits their spatial resolution and require a high bias voltage to achieve an acceptable collection of charges excluding their use for in vivo dosimetry. These disadvantages require the implementation of ionization chambers with improved electrodes. In particular, the spatial resolution of the existing dosimeters can be enhanced with miniaturized detectors, also for in vivo applications. In this context, we developed novel dosimeters by means of Nanotechnologies. Nanocarbons, such as carbon nanotubes (MWCNTs) and graphene, for their low production cost and the fascinating physical properties, are very promising materials to obtain a new generation dosimeter, enclosing all the features of an ideal radiation detector and allowing a net scale passage. The proposed dosimeters open prospective for a new competitive and even distruptive innovation to be employed not only for radiotherapy but also for radiology. Indeed, for radiological diagnostic exams, it is necessary to measure the radiation doses in order to optimize the released dose according to ALARA (As Low As reasonably Achievable) principle, without prejudicing the quality of the radiological investigation
Noivion is introducing a new manufacturing technique for the deposition of thin films called Ionised Jet Deposition (IJD) that offer substantial advantages over comparable solutions in terms of quality, cost and yield. The IJD method consists of a special electron source placed in a vacuum chamber able to generate repetitively very short and intense electric discharges directed into a solid target. The target, composed by the desired coating material, when hit by the discharge, generates a superficial emission of very energetic material in the form of a plasma. The plasma cools down on any object it finds on its way producing a coating on the object itself made of the same material of the target.
Humans coordinate multiple senses for optimal recognition, and so should electronics systems. Presenting a technology breakthrough in sensing with smart materials, a quantum leap in molecular recognition. Sensichips brings together a unique combination of expertise in materials science, analytical chemistry, nanotecnologies and precision analog microelectronics to engage in the development of a next generation microsensors platform. Our miniature sensors will include diverse sensor types, signal conditioning, acquisition electronics and synergistic coordination to improve recognition, in a single microchip
Tecrea has acquired the worldwide and exclusive license to a nanotechnology based delivery platform. This platform functions to deliver of a range of cargos into cells and tissues. The core componant of this nanoparticle based system has been in use in over the counter and off the shelf products for human health and well being for >30 year with an exemplary safety track record . Our discovery is that the core component of these healthcare products form nanoparticles with a range of cargos including plasmids, siRNA, proteins and small organic molecules to efficiently and safely deliver the cargos into a range of cells types and some tissues. These cell types include primary cells, cell lines, stem cells, bacteria and fungi. Tecrea is about to start commercialising a total of 5 products. 4 tools for research purpose and 1 product as a platform for outlicensing to drug companies to reformulate and thus improve drugs with poor potency, saftey liabilities or poor membrane penetration
Polymer based materials Category
Optically transparent polymer (nanostructure transparent polymer, NSTP) materials and technology for encapsulation/coating Solar PV (based on silicon and flexible non silicon materials, such as COGS), OLED, flexible displays, and other optical devices with complex configuration, concentrating systems for PV modules, including plastic lenses, for forming coating layers on Fresnel lenses, in light-emitting diode, camera lens coatings, etc, NSTP could successfully replace glass and multilayer polymer coating for optical devices, protect from UV radiation and humidity, and increase the PV module efficiency.
Geltis produces injectable polymer formulations for advance drug delivery systems for human health and cosmetic surgery application. These systems are liquid at room temperature and can easily encapsulate active pharmaceutical ingredient (API). When injected in the body, they undergo a phase transition, forming a 3D hydrogel structure, which allows controlled and local API release. The composition of the formulations is tunable and can be designed in order to fit the requirements of a specific application, such as definite degradation rate and drug release kinetic. These systems can enhance drug efficacy, improve patient compliance and decrease the therapy cost. Geltis is a business to business company that supports the formulation development goals of pharmaceutical, medical and cosmetic companies
Graphenics, LLC – “Enabling Graphene-based Technologies” Graphenics’s process allows for the easier integration of the nanomaterial graphene into consumer-based goods. Our method combines both the production and transfer of graphene into a single step, that can be customized based on the customer’s needs and application. Graphene is an amazing material that is approximately 200 times stronger than steel, yet, it is extremely lightweight. This allows graphene to be used in a variety of applications from consumer-based electronics to high-tech defense weapons. However, this small material is difficult to produce on a large scale coupled with material integration problems has reduced the impact that graphene has on improving people’s life. Graphenics’s technology overcomes these barriers to provide industries with an easy avenue to utilize graphene in their products
Medfiber is an early-stage venture that develops a biomedical non-invasive fiber optic pressure sensor for diagnostic of urological and urodynamic deseases.
Voltaic Coatings owns the exclusive license to a pending composition of matter patent for a new material created at the University of Delaware. The material transforms the way electronic displays, touch screens, organic lighting, and thin film solar devices are produced. Dr. David Martin, the Chair of the Material Science Department of the University of Delaware, and scientific advisor to Voltaic Coatings, created the materials, ProDOT+, an electro-conductive polymer that possesses superior molecular properties to existing products. The customizability of ProDOT+ will enable our clients to replace the current materials used in the transparent conductor and hole injection layers of their devices. For OEM manufacturers, roll-to-roll manufacturing of lighting, displays, and flexible touch screens is now a cost effective reality. Consider the implications of “newspaper-printing” display screens.
The selected teams from are now attending the two mentoring sessions given by the consultants of Macorig &Co.